despondent

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Definition: (adjective) Feeling or showing profound hopelessness, dejection, discouragement, or gloom. Synonyms: heartsick. Usage: I did my best to take Mike's mind off his problems, but he was too despondent to smile at my corny jokes. Discuss

dispirit

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Definition: (verb) Lower someone's spirits; make downhearted. Synonyms: cast down, deject, depress, dismay, demoralize. Usage: I try to maintain a positive outlook, but the sad stories that are often featured on the nightly news inevitably dispirit me. Discuss